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pentobarbital will lessen the extent or effect of cevimeline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will lower the extent or influence of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of siponimod whi